Molecules in the brain trigger ageing

4 May

inhibited
[http://www.nature.com/news/molecules-in-the-brain-trigger-ageing-1.12891]

Molecules in the brain trigger ageing

Activity in the hypothalamus affects cognitive and physical decline.

Chris Palmer

01 May 2013

The area of the brain that controls growth, reproduction and
metabolism
also kick-starts ageing, according to a study published today in
Nature1. The finding could lead to new treatments for age-related
illnesses, helping people to live longer.

Dongsheng Cai, a physiologist at Albert Einstein College of Medicine
in
New York, and his colleagues tracked the activity of NF-κB — a
molecule
that controls DNA transcription and is involved in inflammation and
the
body’s response to stress — in the brains of mice. They found that
the
molecule becomes more active in the brain area called the
hypothalamus
as a mouse grows older.

Further tests suggested that NF-κB activity helps to determine when
mice
display signs of ageing. Animals lived longer than normal when they
were
injected with a substance that inhibited the activity of NF-κB in
immune
cells called microglia in the hypothalamus. Mice that received a
substance to stimulate the activity of NF-κB died earlier.

“We have provided scientific evidence for the concept that systemic
ageing is influenced by a particular tissue in the body,” says Cai.
Health and well-being

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: